Extreme levels of blood-borne alcohol may result in coma or death.
Alcohol intoxication is the result of drinking alcohol such that it enters the bloodstream faster than it can be metabolized by the body.
Acetate is used by the muscle cells to produce acetyl-Co A using the enzyme acetyl-Co A synthetase, and the acetyl-Co A is then used in the citric acid cycle.
As drinking increases, people become sleepy, or fall into a stupor.
CNS depression and impaired motor co-ordination along with poor judgment increases the likelihood of accidental injury occurring.
In addition to respiratory failure and accidents caused by effects on the central nervous system, alcohol causes significant metabolic derangements.
Because these may have varying reliability and may produce different results than the tests used for law-enforcement purposes, the results from such devices should be conservatively interpreted.
Many informal intoxication tests exist, which, in general, are unreliable and not recommended as deterrents to excessive intoxication or as indicators of the safety of activities such as motor vehicle driving, heavy equipment operation, machine tool use, etc.
Despite this widespread use and alcohol's legality in most countries, many medical sources tend to describe any level of alcohol intoxication as a form of poisoning due to ethanol's damaging effects on the body in large doses.In some systems, these effects are facilitatory and in others inhibitory.Among the neurotransmitter systems with enhanced functions are: GABA The result of these direct effects is a wave of further indirect effects involving a variety of other neurotransmitter and neuropeptide systems, leading finally to the behavioural or symptomatic effects of alcohol intoxication.Ethanol is metabolised to acetaldehyde by alcohol dehydrogenase (ADH), which is found in many tissues, including the gastric mucosa.Acetaldehyde is metabolised to acetate by acetaldehyde dehydrogenase (ALDH), which is found predominantly in liver mitochondria.Law enforcement officers in the United States of America often use breathalyzer units and field sobriety tests as more convenient and rapid alternatives to blood tests.There are also various models of breathalyzer units that are available for consumer use.Several well-known criteria can be used to establish a probable diagnosis.For a physician in the acute-treatment setting, acute alcohol intoxication can mimic other acute neurological disorders, or is frequently combined with other recreational drugs that complicate diagnosis and treatment.After a very high level of consumption, the respiratory system becomes depressed and the person will stop breathing.Comatose patients may aspirate their vomit (resulting in vomitus in the lungs, which may cause "drowning" and later pneumonia if survived).